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Living Donation Forum / Transplantation Immunology Survey

« Last post by tariq_2444 on October 02, 2023, 03:58:00 PM »

Hi! My girlfriend is doing a research project regarding transplantation and immunology for a 3rd Year university project. I would really appreciate any person here taking a little time out of their day to fill in responses whether you are an organ donor or recipient. All the data will be treated with upmost care and no personal information will be requested. It would be a huge help, thank you!

Organ Donor: https://docs.google.com/forms/d/e/1FAIpQLScBq-5fW9uy9VXitx9Gn0AUQKoaTbKVOU9p0Kjf4ddPcLLL_g/viewform?usp=sf_link

Organ Recipient:

https://docs.google.com/forms/d/e/1FAIpQLScyUoEN_g_c_w0K02vVou2vknjXfoR323wop0i6RWM8vM7huQ/viewform?usp=sf_link

Living Donation Forum / October 2023 Living Organ Donor Anniversaries!

« Last post by Clark on October 01, 2023, 07:40:43 AM »

We remember so much this month, as we do every month. So many stories of hope, love, sacrifice, and care. We donors do our best on behalf of another, hoping for the best. Family and friends are generally supportive, recipients generally do well, as do donors. We celebrate the urge to help. We recognize the memories are not all joyful. our heartfelt best wishes for heart’s ease to all suffering due to a loss remembered more poignantly this month. Take good care.

As I compiled this month’s remembrances, I noted that there are wedding anniversaries and birthdays mentioned in what folks have offered to be included in our anniversary calendar. Happy birthday, Tracey! We hope you and your dad, Bruce, are both well! Christa, is Maddox 10 now? We hope so, and that you’re both well! Happy wedding anniversary, Diane and Marvin! We hope all’s well for you both, too!

Do take care, Leslie, Barb, and Rebecca. It’s so hard to be reminded of when a hoped for outcome didn’t happen. We hope you’re held in beloved, loving arms when needed.

Happy anniversaries! Add yours at https://livingdonorsonline.org/donor-experiences/donation-anniversaries/

Forty-seventh anniversary:
Andrew Janollari donated a kidney to his sister, Carol, on October 12th, 1976

Thirty-fourth anniversary:
Tyrone Hyslop donated part of his liver to his sister on October 18th, 1989

Thirty-third anniversary:
Dannielle Hayes donated a kidney to her mother on October 9th, 1990

Twenty-seventh anniversary:
Lisa Moore donated a kidney to her sister on October 17th, 1996
Leslie Moore Boyd donated a kidney to her father, Charles, on October 31st, 1996. He lived three more years, during which he welcomed his last grandchild into this world.

Twenty-fifth anniversary:
Robert S. Burroughs donated a kidney to his sister on October 10th, 1998
Charlotte Singletary donated a kidney to her sister, Cindy Murdock, on October 21st, 1998
Charlotte Singletary donated a kidney to her sister, Cindy Murdock, on October 21st, 1998

Twenty-fourth anniversary:
Jack Hallman donated a kidney to Donna Leubke's recipient, her sister, his friend, on October 19th, 1999

Twenty-second anniversary:
Barb donated a kidney to her brother on October 1st, 2001. He was re-transplanted 6 days later.
Ellen Souviney donated a kidney to a friend on October 2nd, 2001
Michelle Nichols donated a kidney to a stranger on October 29th, 2001
Jennifer Beckwith donated a kidney to her sister on October 30th, 2001

Twenty-first anniversary:
Mary DeLeeuw donated a kidney to a friend on October 8th, 2002
Sylvia Ridley donated a kidney to her mother, Lucy, on October 23rd, 2002
Janice Uible donated a kidney to her husband on October 29th, 2002

Twentieth anniversary:
Tina Alvarez donated a kidney to her sister on October 13th, 2003
Stephanie Powell donated a kidney to a stranger on October 21st, 2003
Marilyn Zeller-Walker donated a kidney to her daughter on October 28th, 2003

Nineteenth anniversary:
Lynn Cosgrove donated a kidney anonymously on October 12th, 2004
Samuel R. Smitty II donated a kidney to an unrelated person on October 20th, 2004
Gladys Sanders donated a kidney to her daughter on October 29th, 2004

Eighteenth anniversary:
Bruce Doty donated a kidney to his daughter, Tracey, on October 12th, 2005, the day before her 23rd birthday.
Angela Dale donated a kidney to her friend, Charles Coats, on October 19th, 2005
Lynda Gammons donated a kidney to her husband, Ian, on October 20th, 2005
Ruth Woodhall donated a kidney to her cousin, Alan, on October 27th, 2005

Seventeenth anniversary:
Michael Joseph donated a kidney to a stranger found on LDO in October, 2006
Patty-Lynn Gouthro donated a kidney to her sister on October 4th, 2006
Bryan Compton donated a kidney to his wife, Debbie, on October 10th, 2006
Vince C. donated a kidney to his wife on October 17th, 2006
Amanda Mathenia donated a kidney to her father, Terry, on October 25th, 2006

Sixteenth anniversary:
Lauren Chavis donated a kidney to Christina Hill on October 2nd, 2007
Tina Schwaderer donated a kidney to David Martin on October 2nd, 2007
Kim Jackson donated her left kidney to her mother on October 5th, 2007
Ann Davis donated a kidney to her husband on October 22nd, 2007
Khalifa Al Shaibani donated a kidney to his brother, Hamad, on October 26th, 2007
Diane Curtiss donated a kidney to her husband on October 30th, 2007

Fifteenth anniversary:
Nathan Pearl donated a kidney to his sister on October 7th, 2008
Edwin E. Rodriguez, Sr., donated a kidney to his son, Edwin E. Rodriguez, Jr., on October 9th, 2008
Anne-Marie Meyer donated her right kidney to her friend Susie on October 14th, 2008
Lorrie Whitfield donated a kidney to her husband on October 15th, 2008
Carole Stueben donated a kidney to her father on October 16th, 2008
Oliver Foggin donated a kidney to a friend on October 17th, 2008
Kathy Harris donated a kidney to her husband on October 23rd, 2008
Sarah McDaniel donated a kidney to a stranger in a list exchange on October 28th, 2008 (her mother received a deceased-donor kidney four weeks later)

Fourteenth anniversary:
Linda donated a kidney to her husband on October 8th, 2009
Faith McKinney donated a kidney to her cousin's husband, Steve Carter, on October 20th, 2009
Carmen Manning donated a kidney to her father on October 23rd, 2009
Phil Hoover gave his left kidney to one of his college professors from more than 20 years ago on October 28th, 2009

Thirteenth anniversary:
Rebecca Chambers Farwell donated a kidney to her husband, Keith, on October 19th, 2010. He died a short time later from a preventable complication.
Scott Jenkins donated a kidney to a stranger in need on October 22nd, 2010

Twelfth anniversary:
Shelby Morris donated a kidney to a friend on October 6th, 2011
Tricia Carter donated a kidney to her sister, Elaine, on October 16th, 2011
Brenda Walsh donated a kidney to her brother, Robert Rhinas, on October 17th, 2011
Tom Carr made a non-directed kidney donation on October 21st, 2011
Linda donated a kidney to her best friend from high school on October 28th, 2011
Sonya Martinez donated a kidney to her husband Jaime, on October 28th, 2011

Eleventh anniversary:
Linda Bernard donated a kidney on October 1st, 2012
Shana Roche donated part of her liver to her father, Michael Cox, on October 4th, 2012
Scott W. Barnes donated a kidney to his uncle, Billy Gene Crum, on October 18th, 2012

Tenth anniversary:
Christa Bolette Hassen donated part of her liver to four week old Maddox Raptosh on October 16th, 2013
Bruce Stanfill donated a kidney to his neighbor, Ben Bott, on October 23rd, 2013
Julie Chahal donated a kidney to her father, Ken, on October 23rd, 2013
June Krueger donated a kidney to her long time friend, Cindy Dischinger, on October 30th, 2013

Ninth anniversary:
Jon Aplin donated part of his liver to his friend, Jaci Rego, on October 2nd, 2014
Angel McCliggott donated a kidney on October 31st, 2014

Eighth anniversary:
Diane R Witte donated a kidney to her husband, Marvin, on their 21st wedding anniversary, October 12th, 2015
Jack Kenneth Omondi Ouko donated a kidney to his sister, Jael Akinyi Ouko, on October 13th, 2015
Lisa Mendpara donated a kidney to her husband, Ris***, on October 14th, 2015

Seventh anniversary:
Donna Aitken donated a kidney to her sister, Karen, on October 25th, 2016

Fourth anniversary:
Tom Davies made a non-directed kidney donation on October 16th 2019
Erin Kirchner donated a kidney anonymously, reportedly to a 14 year old girl in Minnesota, on October 22nd, 2019

Second anniversary:
Anita I. Costello donated a kidney to her husband, Zavier D. Mauldin, on October 25th, 2021

Living Donation in the News / Court case in Massachusetts: Kidney Donor's letter to end recipient of a chain..

« Last post by Clark on September 17, 2023, 02:42:47 PM »

https://www.bloomberglaw.com/public/desktop/document/LarsonvPerryetalDocketNo119cv10203DMassJan302019CourtDocket/2?doc_id=X4C1JG8DIN58IVP76AC7631DIMB

Court document with surprisingly clearly written text explaining why:
1) the donor had copyright protection despite lack of publication,
2) the person who wrote stories inspired by the donor's letter was protected by "fair use", and
3) why the donor's sincere belief that it wasn't "fair use" protected them from a defamation countersuit.

Everyone who has every told their donation story should know about this case. Best wishes, all!

Living Donation in the News / Aborted living-donor liver transplantation in the real-world setting, lessons

« Last post by Clark on September 10, 2023, 06:15:08 PM »

https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext[/color][/font]Aborted living-donor liver transplantation in the real-world setting, lessons from 13 937 cases of Vanguard Multi-center Study of International Living Donor Liver Transplantation Group

Takeo Toshima
Jinsoo Rhu
Young-In Yoon

Sung-Gyu Lee
Toru Ikegami
Kwang-Woong Lee

et al.
American Journal of Transplantation
Published:July 28, 2023
DOI:https://doi.org/10.1016/j.ajt.2023.07.011

Abstract
There are exceedingly uncommon but clearly defined situations where intraoperative abortions are inevitable in living-donor liver transplantation (LDLT). This study aimed to summarize the cases of aborted LDLT and propose a strategy to prevent abortion or minimize donor damage from both recipient and donor sides. We collected data from a total of 43 cases of aborted LDLT out of 13 937 cases from 7 high-volume hospitals in the Vanguard Multi-center Study of the International Living Donor Liver Transplantation Group and reviewed it retrospectively. Of the 43 cases, there were 24 recipient-related abortion cases and 19 donor-related cases. Recipient-related abortions included pulmonary hypertension (n =

, hemodynamic instability (n = 6), advanced hepatocellular carcinoma (n = 5), bowel necrosis (n = 4), and severe adhesion (n = 1). Donor-related abortions included graft steatosis (n = 7), graft fibrosis (n = 5), primary biliary cholangitis (n = 3), anaphylactic shock (n = 2), and hemodynamic instability (n = 2). Total incidence of aborted LDLT was 0.31%, and there was no remarkable difference between the centers. A strategy to minimize additional donor damage by delaying the donor’s laparotomy or trying to open the recipient’s abdomen with a small incision should be effective in preventing some causes of aborted LDLT, such as pulmonary hypertension, advanced cancer, and severe adhesions.

Living Donation in the News / Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National U

« Last post by Clark on September 10, 2023, 06:12:38 PM »

https://www.amjtransplant.org/article/S1600-6135(23)00531-2/fulltext

Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National University Hospital

Suk Kyun Hong

Jae-Yoon Kim
Jaewon Lee

Nam-Joon Yi
Kwang-Woong Lee
Kyung-Suk Suh

et al.
American Journal of Transplantation
Published:June 13, 2023
DOI:https://doi.org/10.1016/j.ajt.2023.06.007

Abstract
Pure laparoscopic donor hepatectomy (PLDH) has become a routine procedure at Seoul National University Hospital, and the pure laparoscopic method is now being applied to liver recipients as well. This study aimed to review the procedure and outcomes of PLDH to identify any areas that required improvement. Data from 556 donors who underwent PLDH between November 2015 and December 2021 and their recipients were retrospectively reviewed. Among these, 541 patients underwent pure laparoscopic donor right hepatectomy (PLDRH). The mean hospital stay of the donor was 7.2 days, and the rate of grade I, II, IIIa, and IIIb complications was 2.2%, 2.7%, 1.3%, and 0.9%, respectively, without any irreversible disabilities or mortalities. The most common early and late major complications in the recipient were intraabdominal bleeding (n = 47, 8.5%) and biliary problems (n = 198, 35.6%), respectively. Analysis of the PLDRH procedure showed that operative time, liver removal time, warm ischemic time, Δhemoglobin%, Δtotal bilirubin%, and postoperative hospital stay decreased significantly as the number of cases accumulated. In conclusion, the operative outcomes of PLDRH improved as the number of cases increased. However, continuous caution is needed because major complications still occur in donors and recipients even after hundreds of cases.

Living Donation in the News / The first successful case of ABO-incompatible living-donor lobar lung transplant

« Last post by Clark on September 10, 2023, 06:10:25 PM »

https://www.amjtransplant.org/article/S1600-6135(23)00457-4/fulltext

CASE REPORT| VOLUME 23, ISSUE 9, P1451-1454, SEPTEMBER 2023

The first successful case of ABO-incompatible living-donor lobar lung transplantation following desensitization therapy

Daisuke Nakajima

Itsuki Yuasa
Hidenao Kayawake

Shiro Baba
Hidefumi Hiramatsu
Hiroshi Date
et al.
American Journal of Transplantation
Published:May 04, 2023
DOI:https://doi.org/10.1016/j.ajt.2023.04.031

Abstract
ABO-incompatible (ABO-I) living-donor lobar lung transplantation (LDLLT) was successfully performed in a 14-year-old girl who suffered from bronchiolitis obliterans due to graft-versus-host disease following hematopoietic stem cell transplantation. In the ABO-I LDLLT procedure, the blood type O patient received a right lower lobe donated from her blood type B father and a left lower lobe donated from her blood type O mother. Desensitization therapy, using rituximab, immunosuppressants, and plasmapheresis, was implemented for 3 weeks prior to transplantation to reduce the production of anti-B antibodies in the recipient and prevent acute antibody-mediated rejection after ABO-I LDLLT.

Living Donation in the News / Lithium and the living kidney donor: Science or stigma?

« Last post by Clark on September 10, 2023, 06:08:28 PM »

https://www.amjtransplant.org/article/S1600-6135(23)00489-6/fulltext

PERSONAL VIEWPOINT| VOLUME 23, ISSUE 9, P1300-1306, SEPTEMBER 2023

Lithium and the living kidney donor: Science or stigma?

Rachel A. Davis

Tyler Branagan
Christopher D. Schneck
Jesse D. Schold
Thida Thant
Bruce Kaplan
American Journal of Transplantation
Published:May 24, 2023
DOI:https://doi.org/10.1016/j.ajt.2023.05.022

Abstract
Nearly 10 000 people are removed from the kidney transplant waiting list each year either due to becoming too ill for transplant or due to death. Live donor kidney transplant (LDKT) provides superior outcomes and survival benefit relative to deceased donor transplant, but the number of LDKT has decreased over the past few years. Therefore, it is of paramount importance that transplant centers employ evaluation processes that safely maximize LDKT. Decisions about donor candidacy should be based on the best available data, rather than on processes prone to bias. Here, we examine the common practice of declining potential donors based solely on treatment with lithium. We conclude that the risk of end-stage renal disease related to lithium treatment is comparable to other generally accepted risks in LDKT. We present this viewpoint to specifically challenge the carte blanche exclusion of individuals taking lithium and highlight the importance of using the best available data relevant to any risk factor, rather than relying on biases, when evaluating potential living kidney donors.

Living Donation in the News / Short- & long-term complications after living donor ileal (intestinal) resection

« Last post by Clark on September 10, 2023, 06:06:36 PM »

https://www.amjtransplant.org/article/S1600-6135(23)00056-4/fulltext

ORIGINAL ARTICLE| VOLUME 22, ISSUE 12, P3053-3060, DECEMBER 2022Short- and long-term complications after living donor ileal resection

Guosheng Wu

Chaoxu Liu
Xile Zhou

Mian Wang
Qingchuan Zhao
Tingbo Liang

et al.
American Journal of Transplantation
DOI:https://doi.org/10.1111/ajt.17193

Intestinal transplantation from deceased donors is the established procedure for patients with irreversible intestinal failure. However, a living-donor intestinal transplant has not been routinely performed yet because of undefined surgical risks to the donor. In this report, we reviewed our experience with living-donor ileal resection from May 1999 to December 2021. A total of 40 living-donor ileal resections were performed for 40 intestinal transplant recipients. Clinical data were prospectively collected and analyzed for postoperative complications after ileal procurement. None of the donors experienced life-threatening complications or mortality. Six (15%) of 40 donors experienced minor operative complications. Transit intestinal graft inadequacy including weight loss, diarrhea, and vitamin B12 deficiency was common early following surgery, but was manageable and disappeared in most cases within a year. All donors had significant reductions in total plasma cholesterol and low-density lipoprotein cholesterol concentrations after donation as compared with the baseline levels. With an average follow-up of 67.8 months, bilateral kidney stones occurred in one donor and gallstones in the other. All the donors have regained their normal capacity for work. Living-donor ileal resection is associated with minimal short- and long-term morbidity and remains an attractive alternative for potential recipients when suitable deceased donors are unavailable.

Living Donation in the News / Impact of having potential living donors on ethnic/racial disparities in access

« Last post by Clark on September 10, 2023, 06:03:00 PM »

https://www.amjtransplant.org/article/S1600-6135(22)29946-8/fulltext

BRIEF COMMUNICATION| VOLUME 22, ISSUE 10, P2433-2442, OCTOBER 2022

Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation

Elisa J. Gordon

Jungwha Lee
Raymond Kang
Juan Carlos Caicedo
American Journal of Transplantation
DOI:https://doi.org/10.1111/ajt.17090

Racial/ethnic disparities persist in patients’ access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates’ receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinical trial of waitlisted candidates (January 1, 2014–December 31, 2019), we evaluated Hispanic and Non-Hispanic White (NHW) KT candidates’ number of PLDs. Multivariable logistic regression assessed the impact of PLDs on transplantation (KT vs. no KT; for KT recipients, LDKT vs. deceased donor KT). A total of 847 candidates were included, identifying as Hispanic (45.8%) or NHW (54.2%). For Site A, both Hispanic (adjusted OR = 2.26 [95% CI 1.13–4.53]) and NHW (OR = 2.42 [1.10–5.33]) candidates with PLDs completing the questionnaire were more likely to receive a KT. For Site B, candidates with PLDs were not significantly more likely to receive KT. Among KT recipients at both sites, Hispanic (Site A: OR = 21.22 [2.44–184.88]; Site B: OR = 25.54 [7.52–101.54]), and NHW (Site A: OR = 37.70 [6.59–215.67]; Site B: OR = 15.18 [5.64–40.85]) recipients with PLD(s) were significantly more likely to receive a LDKT. Our findings suggest that PLDs increased candidates’ likelihood of KT receipt, particularly LDKT. Transplant programs should help candidates identify PLDs early in transplant evaluation.

Living Donation in the News / The living kidney donor profile index fails to discriminate allograft survival:

« Last post by Clark on September 10, 2023, 06:00:45 PM »

https://www.amjtransplant.org/article/S1600-6135(22)24775-3/fulltext

ORIGINAL ARTICLE| VOLUME 23, ISSUE 2, P232-238, FEBRUARY 2023

The living kidney donor profile index fails to discriminate allograft survival: implications for its use in kidney paired donation programs

Georgina L. Irish
Lachlan C. McMichael
Matthew Kadatz

Edward Sharples
John S. Gill

Philip A. Clayton
et al.

American Journal of Transplantation
Published:December 05, 2022
DOI:https://doi.org/10.1016/j.ajt.2022.10.001

Abstract
The inclusion of blood group– and human leukocyte antigen–compatible donor and recipient pairs (CPs) in kidney paired donation (KPD) programs is a novel strategy to increase living donor (LD) transplantation. Transplantation from a donor with a better Living Donor Kidney Profile Index (LKDPI) may encourage CP participation in KPD programs. We undertook parallel analyses using data from the Scientific Registry of Transplant Recipients and the Australia and New Zealand Dialysis and Transplant Registry to determine whether the LKDPI discriminates death-censored graft survival (DCGS) between LDs. Discrimination was assessed by the following: (1) the change in the Harrell C statistic with the sequential addition of variables in the LKDPI equation to reference models that included only recipient factors and (2) whether the LKDPI discriminated DCGS among pairs of prognosis-matched LD recipients. The addition of the LKDPI to reference models based on recipient variables increased the C statistic by only 0.02. Among prognosis-matched pairs, the C statistic in Cox models to determine the association of the LKDPI with DCGS was no better than chance alone (0.51 in the Scientific Registry of Transplant Recipient and 0.54 in the Australia and New Zealand Dialysis and Transplant Registry cohorts). We conclude that the LKDPI does not discriminate DCGS and should not be used to promote CP participation in KPD programs.