| LDO Home | General | Kidney | Liver | Marrow | Experiences | Buddies | Hall of Fame | Calendar | Contact Us |

Author Topic: LKDPI: A Risk Index for Living Donor Kidney Transplantation  (Read 3049 times)

0 Members and 1 Guest are viewing this topic.

Offline Clark

  • Administrator
  • Top 10 Poster!
  • *****
  • Posts: 3,015
  • Please give the gift of life!
    • Living Donors Online!
LKDPI: A Risk Index for Living Donor Kidney Transplantation
« on: January 12, 2016, 09:38:14 AM »
http://onlinelibrary.wiley.com/doi/10.1111/ajt.13709/abstract

A Risk Index for Living Donor Kidney Transplantation
      Allan B. Massie1,2, Joseph Leanza1, Lara M. Fahmy1, Eric K H Chow1, Niraj M. Desai1, Xun Luo1, Elizabeth A. King1, Mary G. Bowring1 andDorry L. Segev1,2,3,*
DOI: 10.1111/ajt.13709

American Journal of Transplantation
Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Abstract
Choosing between multiple living kidney donors, or evaluating offers in kidney paired donation, can be challenging because no metric currently exists for living donor quality. Furthermore, some deceased donor kidneys can result in better outcomes than some living donor kidneys, yet there is no way to compare them on the same scale. To better inform clinical decision-making, we created a living kidney donor profile index (LKDPI) on the same scale as the deceased donor KDPI, using Cox regression and adjusting for recipient characteristics. Donor age over 50 (HR per 10y = 1.151.241.33), elevated body mass index (BMI) (HR per 10 units = 1.011.091.16), African-American race (HR= 1.151.251.37), cigarette use (HR=1.091.161.23), as well as ABO incompatibility (HR= 1.031.271.58), HLA B (HR= 1.031.081.14) mismatches, and DR (HR= 1.041.091.15) mismatches were associated with greater risk of graft loss after living donor transplantation (all p<0.05). Median (IQR) LKDPI score was 13 (1-27); 24.2% of donors had LKDPI<0 (less risk than any DD kidney), and 4.4% of donors had LKDPI>50 (more risk than the median DD kidney). The LKDPI is a useful tool for comparing living donor kidneys to each other and to deceased donor kidneys.

Unrelated directed kidney donor in 2003, recipient and I both well.
620 time blood and platelet donor since 1976 and still giving!
Elected to the OPTN/UNOS Boards of Directors & Executive, Kidney Transplantation, and Ad Hoc Public Solicitation of Organ Donors Committees, 2005-2011
Proud grandpa!

 

 Subscribe in a reader



Copyright © International Association of Living Organ Donors, Inc. All Rights Reserved