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Living Donation Discussion and News => Living Donation in the News => Topic started by: Clark on September 10, 2023, 06:15:08 PM
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https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext)[/color][/font]Aborted living-donor liver transplantation in the real-world setting, lessons from 13 937 cases of Vanguard Multi-center Study of International Living Donor Liver Transplantation Group
Takeo Toshima (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
Jinsoo Rhu (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
Young-In Yoon (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
Sung-Gyu Lee (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
Toru Ikegami (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
Kwang-Woong Lee (https://www.amjtransplant.org/article/S1600-6135(23)00583-X/fulltext#)
et al.
American Journal of Transplantation
Published:July 28, 2023
DOI:https://doi.org/10.1016/j.ajt.2023.07.011 (https://doi.org/10.1016/j.ajt.2023.07.011)
Abstract
There are exceedingly uncommon but clearly defined situations where intraoperative abortions are inevitable in living-donor liver transplantation (LDLT). This study aimed to summarize the cases of aborted LDLT and propose a strategy to prevent abortion or minimize donor damage from both recipient and donor sides. We collected data from a total of 43 cases of aborted LDLT out of 13 937 cases from 7 high-volume hospitals in the Vanguard Multi-center Study of the International Living Donor Liver Transplantation Group and reviewed it retrospectively. Of the 43 cases, there were 24 recipient-related abortion cases and 19 donor-related cases. Recipient-related abortions included pulmonary hypertension (n = 8), hemodynamic instability (n = 6), advanced hepatocellular carcinoma (n = 5), bowel necrosis (n = 4), and severe adhesion (n = 1). Donor-related abortions included graft steatosis (n = 7), graft fibrosis (n = 5), primary biliary cholangitis (n = 3), anaphylactic shock (n = 2), and hemodynamic instability (n = 2). Total incidence of aborted LDLT was 0.31%, and there was no remarkable difference between the centers. A strategy to minimize additional donor damage by delaying the donor’s laparotomy or trying to open the recipient’s abdomen with a small incision should be effective in preventing some causes of aborted LDLT, such as pulmonary hypertension, advanced cancer, and severe adhesions.