Hemosiderosis Does Not Affect Liver Function and Regeneration in Living Liver Do

[Clark]

http://onlinelibrary.wiley.com/doi/10.1111/ajt.12504/abstract

Donor Hemosiderosis Does Not Affect Liver Function and Regeneration in the Setting of Living Donor Liver Transplantation
O. Shaked1, A. Gonzalez1, R. Bahirwani2, E. Furth3, E. Siegelman4, A. Shaked1,*, K. Olthoff1, K. R. Reddy2
DOI: 10.1111/ajt.12504
American Journal of Transplantation
Early View (Online Version of Record published before inclusion in an issue)

Abstract
Living donor liver transplantation (LDLT) demands a careful assessment of abnormal findings discovered during the evaluation process to determine if there will be any potential risks to the donor or recipient. Varying degrees of elevated hepatic iron levels are not uncommonly seen in otherwise healthy individuals. We questioned whether mild expression of hemosiderin deposition presents a safety concern when considering outcomes of living donation for both the donor and the recipient. We report on three LDLT patients who were found to have low- to moderate-grade hemosiderin deposition on liver biopsy. All other aspects of their evaluation proved satisfactory, and the decision was made to proceed with donation. There were no significant complications in the donors, and all demonstrated complete normalization of liver function postoperatively, with appropriate parenchymal regeneration. The recipients also had unremarkable postoperative recovery. We conclude that these individuals can be considered as potential donors after careful evaluation.