« Reply #1 on: August 05, 2015, 07:48:56 AM »
http://onlinelibrary.wiley.com/doi/10.1111/ajt.13414/fullEditorialThe Best-Laid Schemes of Mice and Men Often Go Awry; How Should We Repair Them?S. E. Gentry, D. L. SegevDOI: 10.1111/ajt.13414American Journal of TransplantationOptimization algorithms have played a central role in matching for kidney paired donation to achieve the greatest benefit [1]. In practice in the United States, matches selected using optimization are frequently scuttled, either because one or more of the pairs has already matched in a different registry, or because a donor turns out to be unacceptable to, or has a positive crossmatch with, a matched recipient [2]. These failed matches pose a challenge for matching systems: what should then be done with the pairs involved? ...the regrettable consequence of having multiple competing KPD registries in the United States, with many pairs listed in more than one registry, is that the registries drive each other to perform match runs very frequently. The more frequent the match runs, the less static optimization can contribute to increasing transplant opportunities. If a registry performs a match run every time a new pair joins, then all of the static optimization methods that have ever been described in the transplantation literature are rendered useless. There has been a race to the bottom in that registries forced by competition to perform match runs very frequently cannot take advantage of mathematical optimization, and likely fewer transplants are accomplished nationwide as a result. A different approach, dynamic optimization, could conceivably allow frequent match runs without compromising the number of transplants performed, but dynamic methods have not taken hold in practice.
« Last Edit: August 05, 2015, 07:51:18 AM by Clark »
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Unrelated directed kidney donor in 2003, recipient and I both well.
620 time blood and platelet donor since 1976 and still giving!
Elected to the OPTN/UNOS Boards of Directors & Executive, Kidney Transplantation, and Ad Hoc Public Solicitation of Organ Donors Committees, 2005-2011
Proud grandpa!