« on: May 08, 2017, 01:18:04 PM »
http://atcmeetingabstracts.com/abstract/outcome-of-adult-living-donor-renal-transplants-in-different-era-analysis-of-unos-database/Outcome of Adult Living Donor Renal Transplants in Different Era: Analysis of UNOS Database.V. Whittaker, R. Gruessner, M. Laftavi, Z. Acun, A. Gruessner.Surgery, State University New York, Syracuse, NYMeeting: 2017 American Transplant CongressAbstract number: A235Background:Living donation is the potential solution to increasing donor donor shortage. This retrospective analysis of UNOS database analyses the outcome of living donor transplantation across 4 eras and report the results in adults .Methods: Retrospective analysis all living donation performed in United States 1987 -2015. The period was divided into era 1987-1994, 1995-2001, 2002-2008 and 2009-2015. The outcome in adults transplant recipients were analyzed. Test of equality over strata by Log Rank and Wilcoxon Statistics for data analysis. P value of <0.05 was considered significant.Results: A total of 114,620 adult patients were analysed. There was significant improvement in graft survival in adults with each successive era. Five year adult survival:76.6, 79.7, 83.1 and 85.4 with each successive era. 10 years outcomes:graft survival rates 56.1, 58.6 and 62.6% with each successive era. Trend persist in year 15 with 37.7% first era vs 39.98% second era. Rank statistics and test of equality over strata showed p value <0.0001. Living donor rates were 23, 35, 40 and 35% for each successive era. Median age 36, 43, 48, 50 with each successive era, donor age 37, 39, 41, 43 years respectively. Biological relatedness: 93.6, 76.9, 62.5 and 50.1%. T50% Living vs DD 11.6 vs 7, 12.2 vs 8.4, >14.3 vs 9.3 years in each successive era.See [Table1] and [Figure1]Conclusion:Significant improvement graft survival adult living donor transplants in successive era despite increased recipient, donor age and less relatedness. Further studies will elucidate the factors leading to improved outcomes.CITATION INFORMATION: Whittaker V, Gruessner R, Laftavi M, Acun Z, Gruessner A. Outcome of Adult Living Donor Renal Transplants in Different Era: Analysis of UNOS Database. Am J Transplant. 2017;17 (suppl 3).
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Unrelated directed kidney donor in 2003, recipient and I both well.
625 time blood and platelet donor since 1976 and still giving!
Elected to the OPTN/UNOS Boards of Directors & Executive, Kidney Transplantation, and Ad Hoc Public Solicitation of Organ Donors Committees, 2005-2011
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