When I was in the workup process, I mentioned to my personal physician that I was considering donation. He noted that it was laudable, but it would be the end of my NSAID use, which he knew was at least moderate. I have osteoarthritis in my thumbs ( when it first developed I dropped a $7k GPS into the everglades while doing environmental work ) and NSAIDS were a constant companion for endurance cycling and backpacking. So the idea of giving up NSAIDS was a real wet blanket on the idea of donation. Fortunately, I stumbled on the following scholarly article from the NIH on the use of natural alternatives to NSAIDS:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011108/ or you can search for "Natural anti-inflammatory agents for pain relief - NCBI - NIH" . I settled into the use of turmeric(curcurin) and green tea with good results.
Most doctors/nurses in the medical community won't even discuss natural alternatives. Fortunately, the consulting nephrologist during my workup was Indian. When asked about the alternatives I was using, she smiled and said "yes, use turmeric and green tea, it's been working in India for millenia".
I am currently 1 month post-donation and don't have enough activity yet for my aches and pains to return. But prior to surgery I experimentally gave up my NSAIDs and used green tea and turmeric for several months during heavy workout activity with what I found to be adequate results. The NIH article cited is really down on NSAIDs and pretty much says we shouldn't be taking them anyway.
The nephrologist would not give me hard guidelines, but said NSAIDs could be used occasionally and low-dose aspirin was OK for cardiac protection. So between the natural alternatives and the potential to use a few NSAIDS in a pinch, I think I will be OK.