Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

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http://www.sciencedirect.com/science/article/pii/S2352872915000330

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment
Andrea R. Zammita, b, Mindy J. Katza, b, Molly E. Zimmermana, b, Markus Bitzerc, Richard B. Liptona, b, d, ,
doi:10.1016/j.dadm.2014.12.002

Abstract
Background
Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI).

Methods
The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45–59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI).

Results
Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models.

Conclusion
At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.