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#21
Living Donation in the News / India: Couple Dies After Woman...
Last post by Clark - September 01, 2025, 02:16:19 PMhttps://www.timesnownews.com/health/couple-dies-after-woman-donates-liver-to-husband-what-to-know-about-post-transplant-recovery-article-152543701
Couple Dies After Woman Donates Liver to Husband: What to Know About Post-Transplant Recovery
Authored by:
Ashima Sharda Mahindra
A couple from Pune died days after the wife donated part of her liver to the 45-year-old husband, who went into a fatal cardiogenic shock after the surgery. According to doctors, the woman's death is attributed to septic shock and multi-organ failure. The case highlights the importance of understanding post-transplant recovery, including risks, complications, and critical care needed after such major surgeries.
A woman donor from Pune died days after her husband passed away following liver transplant surgery last week, doctors said. The 45-year-old man, identified as Bapu Komkar, underwent the surgery after Kamini donated a part of her liver. According to doctors, Bapu suffered a post-operative cardiogenic shock, and Kamini's death is attributed to septic shock and multi-organ failure.
News reports say Maharashtra's health department has issued a formal notice demanding all procedural and medical details from the hospital to investigate the incident thoroughly.
Husband suffered from end-stage liver cirrhosis
Doctors say Bapu was suffering from end-stage liver cirrhosis, and Kamini had volunteered as a live donor. However, according to the hospital, a thorough pre-surgical counselling risk was provided to the couple. After the surgery, Bapu's condition deteriorated rapidly, and he succumbed.
While Kamini did show signs of recovery initially, she later developed septic shock and, despite all efforts, could not be saved.
What is cardiogenic shock?
A cardiogenic or hypotensive shock happens when your body's circulatory system fails to move oxygenated blood and nutrients to cells, leading to multi-organ failure despite advanced treatment.
Experts say it is a medical emergency characterized by a dangerously low cardiac output, which causes inadequate blood flow to vital organs. It is commonly caused by a severe heart attack, but other heart conditions can also lead to it.
Why is an organ transplant done?
According to doctors, organ transplantation is done to save lives when vital organs like the heart, liver, kidneys, lungs, or pancreas begin to fail or have stopped working due to illness, injury, or genetic conditions. The procedure replaces the non-functioning organ with a healthy one from a donor, with matching of the same blood group, and offers a chance to extend life and improve the patient's quality of life.
While organ donation and transplantation save many lives across the world every year, it is important to understand that living organ donors undertake a greater risk of having surgery than those who have passed. Also, sometimes, organ transplants fail, or the recipient's body rejects the organ after the transplant.
What is post-transplant recovery?
According to doctors, post-transplant recovery involves carefully following schedules of medicine, a healthy diet, and slowly taking care of physical health after any operation. Early ambulation, monitoring vital signs like temperature and blood pressure, and attending frequent follow-up appointments are also essential for monitoring the new organ's function and managing overall health.
Liver transplant is among the riskiest surgeries, as the patient's recovery would be lifelong and needs adherence to prescribed immunosuppressant medications so that there is no organ rejection. Also, doctors suggest a healthy and balanced diet, avoiding harmful substances like alcohol and tobacco, and gradual physical activity as advised by doctors.
Key aspects of recovery also include good hygiene, which can help prevent infections; regular follow-up appointments for monitoring; and prompt reporting of any new symptoms like fever or jaundice to your transplant team. At the hospital, specialised equipment will be there to monitor your recovery, providing fluids and medications through tubes and drips until you can breathe independently and fluid balance is stable. Mostly, doctors will discharge you when your pain is controlled, you drink and eat well, and can walk with minimal difficulty.
Couple Dies After Woman Donates Liver to Husband: What to Know About Post-Transplant Recovery
Authored by:
Ashima Sharda Mahindra
A couple from Pune died days after the wife donated part of her liver to the 45-year-old husband, who went into a fatal cardiogenic shock after the surgery. According to doctors, the woman's death is attributed to septic shock and multi-organ failure. The case highlights the importance of understanding post-transplant recovery, including risks, complications, and critical care needed after such major surgeries.
A woman donor from Pune died days after her husband passed away following liver transplant surgery last week, doctors said. The 45-year-old man, identified as Bapu Komkar, underwent the surgery after Kamini donated a part of her liver. According to doctors, Bapu suffered a post-operative cardiogenic shock, and Kamini's death is attributed to septic shock and multi-organ failure.
News reports say Maharashtra's health department has issued a formal notice demanding all procedural and medical details from the hospital to investigate the incident thoroughly.
Husband suffered from end-stage liver cirrhosis
Doctors say Bapu was suffering from end-stage liver cirrhosis, and Kamini had volunteered as a live donor. However, according to the hospital, a thorough pre-surgical counselling risk was provided to the couple. After the surgery, Bapu's condition deteriorated rapidly, and he succumbed.
While Kamini did show signs of recovery initially, she later developed septic shock and, despite all efforts, could not be saved.
What is cardiogenic shock?
A cardiogenic or hypotensive shock happens when your body's circulatory system fails to move oxygenated blood and nutrients to cells, leading to multi-organ failure despite advanced treatment.
Experts say it is a medical emergency characterized by a dangerously low cardiac output, which causes inadequate blood flow to vital organs. It is commonly caused by a severe heart attack, but other heart conditions can also lead to it.
Why is an organ transplant done?
According to doctors, organ transplantation is done to save lives when vital organs like the heart, liver, kidneys, lungs, or pancreas begin to fail or have stopped working due to illness, injury, or genetic conditions. The procedure replaces the non-functioning organ with a healthy one from a donor, with matching of the same blood group, and offers a chance to extend life and improve the patient's quality of life.
While organ donation and transplantation save many lives across the world every year, it is important to understand that living organ donors undertake a greater risk of having surgery than those who have passed. Also, sometimes, organ transplants fail, or the recipient's body rejects the organ after the transplant.
What is post-transplant recovery?
According to doctors, post-transplant recovery involves carefully following schedules of medicine, a healthy diet, and slowly taking care of physical health after any operation. Early ambulation, monitoring vital signs like temperature and blood pressure, and attending frequent follow-up appointments are also essential for monitoring the new organ's function and managing overall health.
Liver transplant is among the riskiest surgeries, as the patient's recovery would be lifelong and needs adherence to prescribed immunosuppressant medications so that there is no organ rejection. Also, doctors suggest a healthy and balanced diet, avoiding harmful substances like alcohol and tobacco, and gradual physical activity as advised by doctors.
Key aspects of recovery also include good hygiene, which can help prevent infections; regular follow-up appointments for monitoring; and prompt reporting of any new symptoms like fever or jaundice to your transplant team. At the hospital, specialised equipment will be there to monitor your recovery, providing fluids and medications through tubes and drips until you can breathe independently and fluid balance is stable. Mostly, doctors will discharge you when your pain is controlled, you drink and eat well, and can walk with minimal difficulty.
#22
Living Donation in the News / AI Platform helps UNOS fulfill...
Last post by Clark - September 01, 2025, 02:01:57 PMhttps://www.servicenow.com/customers/unos.html
UNOS fulfills its life-saving mission
The ServiceNow AI Platform helps nonprofit coordinate thousands of life-saving organ transplants each year...
UNOS fulfills its life-saving mission
The ServiceNow AI Platform helps nonprofit coordinate thousands of life-saving organ transplants each year...
#23
Living Donation in the News / India: Role of agents in livin...
Last post by Clark - September 01, 2025, 01:57:05 PMhttps://www.newindianexpress.com/states/kerala/2025/Aug/29/role-of-agents-in-living-organ-donations-a-concern-kovalam-mla-vincent
Role of agents in living organ donations a concern
Kovalam MLA M Vincent acknowledged the presence of an 'organ mafia' involved in living organ donation, during the launch of the Organ Foundation of Kerala (ORFOK), a charitable trust supporting organ transplant recipients, in Thiruvananthapuram on Friday.
The Kovalam MLA admitted the role of agents in exploiting poor individuals, especially in the coastal areas of Thiruvananthapuram. He highlighted the difficulties MLAs face when certifying affidavits for the living donor process.
"There is a mafia involved in living organ donation. We understand the risks in certifying documents, but we are left with few options to save a patient's life," Vincent said.
He suggested that the government should provide jobs to donors or their families to prevent the financial exploitation surrounding organ donation.
Earlier, the MLAs had called for simplifying the procedures for living organ donations in the state, in the Legislative Assembly.
However, health experts pointed out that these rules were introduced after reports of vulnerable populations, including single mothers, being lured into donating their organs for monetary gain.
Dr Basil Saju, Joint Director of K-SOTTO, stated that living donation procedures have been made more stringent to protect vulnerable individuals.
He also recommended that provisions should be made to ensure the health and safety of living donors.
Health experts at the event emphasised the importance of following global ethical standards in organ donation.
Role of agents in living organ donations a concern
Kovalam MLA M Vincent acknowledged the presence of an 'organ mafia' involved in living organ donation, during the launch of the Organ Foundation of Kerala (ORFOK), a charitable trust supporting organ transplant recipients, in Thiruvananthapuram on Friday.
The Kovalam MLA admitted the role of agents in exploiting poor individuals, especially in the coastal areas of Thiruvananthapuram. He highlighted the difficulties MLAs face when certifying affidavits for the living donor process.
"There is a mafia involved in living organ donation. We understand the risks in certifying documents, but we are left with few options to save a patient's life," Vincent said.
He suggested that the government should provide jobs to donors or their families to prevent the financial exploitation surrounding organ donation.
Earlier, the MLAs had called for simplifying the procedures for living organ donations in the state, in the Legislative Assembly.
However, health experts pointed out that these rules were introduced after reports of vulnerable populations, including single mothers, being lured into donating their organs for monetary gain.
Dr Basil Saju, Joint Director of K-SOTTO, stated that living donation procedures have been made more stringent to protect vulnerable individuals.
He also recommended that provisions should be made to ensure the health and safety of living donors.
Health experts at the event emphasised the importance of following global ethical standards in organ donation.
#24
Living Donation in the News / Re: A living legacy: Donors wh...
Last post by Clark - September 01, 2025, 01:54:10 PM #25
Living Donation in the News / Re: A living legacy: Donors wh...
Last post by Clark - September 01, 2025, 01:53:47 PM #26
Living Donation in the News / A living legacy: Donors who gi...
Last post by Clark - September 01, 2025, 01:53:21 PMhttps://newsnetwork.mayoclinic.org/discussion/a-living-legacy-donors-who-give-hope-and-healing/
A living legacy: Donors who give hope and healing
Carey Stanton
August 29, 2025
[event with video]
A living legacy: Donors who give hope and healing
Carey Stanton
August 29, 2025
[event with video]
#27
Living Donation in the News / Global variation in living don...
Last post by Clark - September 01, 2025, 01:49:08 PMhttps://www.sciencedirect.com/science/article/abs/pii/S1600613525002023
Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: Initial insights from the International LDLT Registry
The LDLTregistry.org Collaborative
American Journal of Transplantation
Volume 25, Issue 8, August 2025, Pages 1735-1745
Abstract
Living donor liver transplantation (LDLT) is crucial for addressing organ scarcity and improving survival and quality of life. Variations in practices and outcomes are influenced by geographic, economic, and cultural factors. This study examined the association between short-term LDLT outcomes and the Human Development Index (HDI), a composite metric ranking countries by life expectancy, education, and income. Data from September 2023 to June 2024 were prospectively collected through the International LDLT Registry, involving 70 institutions from 26 countries. This prospective global cohort included 1575 pairs (3150 cases). Donors from very high HDI regions had a higher prevalence of comorbidities (17.4%) than those from low HDI regions (1.2%; P < .001). Very high HDI regions showed lower donor complication rates (9.8%) than lower HDI regions (21.9%; P < .001). Multivariable analysis indicated significantly reduced short-term postoperative donor morbidity in very high HDI regions (odds ratio, 0.32; 95% confidence interval, 0.23-0.44; P < .001). Failure-to-rescue rates were substantially higher in low HDI regions (83.3% vs 2.3%; P < .001). The study highlights the significant disparities in LDLT practices and short-term outcomes across HDI levels, emphasizing the need for global cooperation to standardize practices and enhance care quality to ensure equitable access to liver transplantation worldwide.
Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: Initial insights from the International LDLT Registry
The LDLTregistry.org Collaborative
American Journal of Transplantation
Volume 25, Issue 8, August 2025, Pages 1735-1745
Abstract
Living donor liver transplantation (LDLT) is crucial for addressing organ scarcity and improving survival and quality of life. Variations in practices and outcomes are influenced by geographic, economic, and cultural factors. This study examined the association between short-term LDLT outcomes and the Human Development Index (HDI), a composite metric ranking countries by life expectancy, education, and income. Data from September 2023 to June 2024 were prospectively collected through the International LDLT Registry, involving 70 institutions from 26 countries. This prospective global cohort included 1575 pairs (3150 cases). Donors from very high HDI regions had a higher prevalence of comorbidities (17.4%) than those from low HDI regions (1.2%; P < .001). Very high HDI regions showed lower donor complication rates (9.8%) than lower HDI regions (21.9%; P < .001). Multivariable analysis indicated significantly reduced short-term postoperative donor morbidity in very high HDI regions (odds ratio, 0.32; 95% confidence interval, 0.23-0.44; P < .001). Failure-to-rescue rates were substantially higher in low HDI regions (83.3% vs 2.3%; P < .001). The study highlights the significant disparities in LDLT practices and short-term outcomes across HDI levels, emphasizing the need for global cooperation to standardize practices and enhance care quality to ensure equitable access to liver transplantation worldwide.
#28
Living Donation in the News / Renal Transplantation in Older...
Last post by Clark - September 01, 2025, 01:45:38 PMhttps://link.springer.com/article/10.1007/s40472-024-00438-4
Renal Transplantation in Older Adults, an Updated Review Open access[/color] Published: 23 August 2024[/color] Volume 11, pages 153–159, (2024)Matthew W. Black, et al.
Current Transplantation Reports
Abstract
Purpose of Review
The purpose of this paper will be to review the most recent literature regarding renal transplantation in an older population. We aim to bring the reader up to date on this topic, and see what challenges are posed by transplanting this ever increasing population.
Recent Findings
Renal transplantation in older adults is a continually evolving field. We review outcomes for older patients in remaining on dialysis, outcomes with living donors, outcomes vs younger patients, readmission, frailty, quality of life, immunosuppressant management, and our own centers experience.
Summary
We show, through various papers, that outcomes for older adults are better with receiving a kidney transplant than staying on dialysis. Outcomes for older recipients vs younger recipients are also acceptable, especially when one factors in death censored graft survival. Older patients also require special consideration to keep their readmission rate low, balance their immunosuppressant requirements, and correctly evaluate their frailty.
Renal Transplantation in Older Adults, an Updated Review Open access[/color] Published: 23 August 2024[/color] Volume 11, pages 153–159, (2024)Matthew W. Black, et al.
Current Transplantation Reports
Abstract
Purpose of Review
The purpose of this paper will be to review the most recent literature regarding renal transplantation in an older population. We aim to bring the reader up to date on this topic, and see what challenges are posed by transplanting this ever increasing population.
Recent Findings
Renal transplantation in older adults is a continually evolving field. We review outcomes for older patients in remaining on dialysis, outcomes with living donors, outcomes vs younger patients, readmission, frailty, quality of life, immunosuppressant management, and our own centers experience.
Summary
We show, through various papers, that outcomes for older adults are better with receiving a kidney transplant than staying on dialysis. Outcomes for older recipients vs younger recipients are also acceptable, especially when one factors in death censored graft survival. Older patients also require special consideration to keep their readmission rate low, balance their immunosuppressant requirements, and correctly evaluate their frailty.
#29
Living Donation in the News / Long-Term Outcomes of Living K...
Last post by Clark - September 01, 2025, 01:41:36 PMhttps://www.researchgate.net/publication/395056053_Long-Term_Outcomes_of_Living_Kidney_Donors_Left_with_Multiple_Renal_Arteries_A_Retrospective_Cohort_Study_from_a_Single_Center
Long-Term Outcomes of Living Kidney Donors Left with Multiple Renal Arteries: A Retrospective Cohort Study from a Single Center
Thomas Kurz, et al.
Journal of Clinical Medicine (JCM)
August 202514(17):6121
DOI:10.3390/jcm14176121
Abstract
Background: The presence of multiple renal arteries (MRAs) is a common anatomical variant in living kidney donors. While MRAs are not considered a contraindication to donation, it remains uncertain whether leaving the donor with a kidney containing MRAs affects long-term outcomes. This study aimed to evaluate renal and clinical outcomes in donors based on the vascular anatomy of the remnant kidney. Methods: We conducted a retrospective cohort study of living kidney donors who underwent nephrectomy at our institution between 2011 and 2016. Donors were categorized according to the vascular anatomy of the remaining kidney: single renal artery (SRA) vs. multiple renal arteries (MRAs). Data on renal function, hypertension, diabetes mellitus, and cardiovascular events were collected at baseline and follow-up. The primary outcome was long-term renal function, which was measured by the estimated glomerular filtration rate (eGFR). Secondary outcomes included clinical comorbidities and postoperative complications. Results: Among 190 donors, 132 had a remaining kidney with a single artery and 58 had MRAs. Over a median follow-up of 89.5 months (SRA) and 74.5 months (MRA), there were no significant differences in eGFR (SRA: 66 mL/min vs. MRA: 65 mL/min, p = 0.60), serum creatinine (p = 0.86), or the incidence of hypertension (31.8% vs. 34.5%, p = 0.35). Rates of diabetes mellitus and cardiovascular events were similarly low and comparable between groups. Conclusions: Living kidney donors left with a remnant kidney containing multiple renal arteries have similar long-term renal function and clinical outcomes as those with a single renal artery. These findings support the feasibility of MRA retention in donor selection and contribute to evidence-based surgical planning and donor counseling.
Long-Term Outcomes of Living Kidney Donors Left with Multiple Renal Arteries: A Retrospective Cohort Study from a Single Center
Thomas Kurz, et al.
Journal of Clinical Medicine (JCM)
August 202514(17):6121
DOI:10.3390/jcm14176121
Abstract
Background: The presence of multiple renal arteries (MRAs) is a common anatomical variant in living kidney donors. While MRAs are not considered a contraindication to donation, it remains uncertain whether leaving the donor with a kidney containing MRAs affects long-term outcomes. This study aimed to evaluate renal and clinical outcomes in donors based on the vascular anatomy of the remnant kidney. Methods: We conducted a retrospective cohort study of living kidney donors who underwent nephrectomy at our institution between 2011 and 2016. Donors were categorized according to the vascular anatomy of the remaining kidney: single renal artery (SRA) vs. multiple renal arteries (MRAs). Data on renal function, hypertension, diabetes mellitus, and cardiovascular events were collected at baseline and follow-up. The primary outcome was long-term renal function, which was measured by the estimated glomerular filtration rate (eGFR). Secondary outcomes included clinical comorbidities and postoperative complications. Results: Among 190 donors, 132 had a remaining kidney with a single artery and 58 had MRAs. Over a median follow-up of 89.5 months (SRA) and 74.5 months (MRA), there were no significant differences in eGFR (SRA: 66 mL/min vs. MRA: 65 mL/min, p = 0.60), serum creatinine (p = 0.86), or the incidence of hypertension (31.8% vs. 34.5%, p = 0.35). Rates of diabetes mellitus and cardiovascular events were similarly low and comparable between groups. Conclusions: Living kidney donors left with a remnant kidney containing multiple renal arteries have similar long-term renal function and clinical outcomes as those with a single renal artery. These findings support the feasibility of MRA retention in donor selection and contribute to evidence-based surgical planning and donor counseling.
#30
Living Donation in the News / Outcomes and motivations in un...
Last post by Clark - September 01, 2025, 01:32:50 PMhttps://www.sciencedirect.com/science/article/abs/pii/S1600613525001509?utm_source=miragenews&utm_medium=miragenews&utm_campaign=news
Outcomes and motivations in unspecified (nondirected altruistic) kidney donation: Results from a United Kingdom prospective cohort study
Hannah Maple, et al.
American Journal of Transplantation
Available online 28 March 2025
In Press, Corrected Proof
https://doi.org/10.1016/j.ajt.2025.03.021
Abstract
Unspecified kidney donors (UKDs) increase the number of high-quality kidneys available for transplantation. This study aimed to determine whether the practice was acceptable, based on the noninferiority of donor physical and psychosocial outcomes when compared to specified kidney donors (SKDs). This longitudinal, prospective cohort study investigated potential living kidney donors from across all 23 UK adult kidney transplant centers. Participants completed validated questionnaires at 4 time points (recruitment, 2-4 weeks predonation, 3- and 12-months postdonation). Clinical outcome data were collected from National Health Service Blood and Transplant. Three hundred seventy-three (of 837 recruited; 45.7%) went on to donate (November 2016 to January 2021). There were no differences in donation rates (204 SKDs [54.7%] vs 169 UKDs [45.3%]; P = .944). Both groups reported being motivated by the desire to help someone (P = .157). Tests for noninferiority indicated that UKDs do no worse than SKDs on psychosocial or clinical outcomes over 12 months, and costs are similar (P > .05). This is the world's largest prospective observational study comparing SKDs and UKDs. It demonstrates no differences in primary motivation, donation rates, regret, cost, or psychosocial and physical outcomes. These data should reassure transplant professionals and potential donors and can bolster confidence in the practice around the world.
Outcomes and motivations in unspecified (nondirected altruistic) kidney donation: Results from a United Kingdom prospective cohort study
Hannah Maple, et al.
American Journal of Transplantation
Available online 28 March 2025
In Press, Corrected Proof
https://doi.org/10.1016/j.ajt.2025.03.021
Abstract
Unspecified kidney donors (UKDs) increase the number of high-quality kidneys available for transplantation. This study aimed to determine whether the practice was acceptable, based on the noninferiority of donor physical and psychosocial outcomes when compared to specified kidney donors (SKDs). This longitudinal, prospective cohort study investigated potential living kidney donors from across all 23 UK adult kidney transplant centers. Participants completed validated questionnaires at 4 time points (recruitment, 2-4 weeks predonation, 3- and 12-months postdonation). Clinical outcome data were collected from National Health Service Blood and Transplant. Three hundred seventy-three (of 837 recruited; 45.7%) went on to donate (November 2016 to January 2021). There were no differences in donation rates (204 SKDs [54.7%] vs 169 UKDs [45.3%]; P = .944). Both groups reported being motivated by the desire to help someone (P = .157). Tests for noninferiority indicated that UKDs do no worse than SKDs on psychosocial or clinical outcomes over 12 months, and costs are similar (P > .05). This is the world's largest prospective observational study comparing SKDs and UKDs. It demonstrates no differences in primary motivation, donation rates, regret, cost, or psychosocial and physical outcomes. These data should reassure transplant professionals and potential donors and can bolster confidence in the practice around the world.