Im just wondering

[hafriz]

Hello fellas.

I was on one of my friend last nite and he told me there is a way to reduce a kidnye rejection and longer time of kidney life.
it is trought Bone marrow transplant first from the donor and then the kidney transplant begin.

this method is now a practice in a few country such as singapore.

Have anyone hear about this method?


cheers

[Michael]

It's called "mixed chimerism". It's still in clinical trials in the US. Here's a link to an article from a few years ago on the topic: http://www.immunetolerance.org/news/2009/02/first-subject-transplanted-expanded-study-mixed-chimerism-kidney-transplantation

[vari]

We asked my husband's possible transplant surgeon at Weill Cornell about this and he said that there were some complications so the project was suspended.This was past November and I am not sure if anything has changed since then.But if it can be done in Singapore then why not here I wonder!

[Michael]

You're right--the study has been suspended. Here's the listing on clinicaltrials.gov, and it says "the study has been suspended" at the top.

Interesting that the Immune Tolerance Network web site still shows the project as active. However, they do post an abstract from a presentation at the American Transplant Congress in May 2011, noting complications in some recipients of a kidney and bone marrow. The concluding sentence of the abstract is "This study has been suspended, and follow-up histopathological and clinical assessments are planned."

More here: http://1.usa.gov/zyZJCP

Thanks for the nudge to research this issue further!

[hafriz]

bone marrow transplant is painfull.
the time taken is about 3 week if im not mistaken.
first bone marrow transplant. a week after that or 10 days after bone marrow. proceed with kidney transplant..
roughly it takes about 3 week for transplant i think

[Fr Pat]

     If I'm not mistaken, there are now two different ways of extracting the needed cells for marrow transplant. One is the older (painful) way in which the cells must be extracted from the center of a large bone (hip) by means of a big needle. The other is to extract the cells from the blood of the donor, in several stages, after stimulating the donor to produce more. This appears to be no more painful than blood donation. I'm not an expert on this, but just passing along stuff I have read of. More detailed info on bone marrow donation by clicking the site at the upper left of this home page, or by going to www.marrow.org
    Fr. Pat

[Karol]

I have a friend who completed the chimerism clinical trial at Northwestern. She received bone marrow and a kidney from her husband and she is now off all immunosuppression medications. You can read her story here http://ihatedialysis.com/forum/index.php?topic=17365.0