Long-term risk of ESRD attributable to live kidney donation: matching with healt

[Clark]

http://livingdonorsarepeopletoo.com/another-look-at-living-kidney-donors-end-stage-renal-disease-risk/
http://www.immunologyreport.com/ATC2013/pdf/Lockridge.pdf

Long-term risk of ESRD attributable to live kidney donation: matching with healthy non-donors.
Muzaale A, Massie A, Wainright J, McBride M, Wang M, Segev D.
Presented at the 2013 American Transplant Congress; May 18–22, 2013; Seattle, Washington. Abstract 565.

The incidence of ESRD at 15 years was eightfold higher for live kidney donors (0.31%) than for healthy matched controls (0.04%). Black donors had the highest incidence of ESRD (0.75%), and white donors had the lowest incidence of ESRD (0.23%).

[Fr Pat]

     From the summary it looks like this study is a big improvement over some previous studies since it tries to compare living kidney donors with non-donors of the same health status. Previous studies comparing donors with the general population may be less accurate, because donors have successfully passed so many tests and exams that they would be healthier than the general population to start with. One element that seems to be missing (only an oral summary has been published) is to take into account whether there is any difference between donors who are blood-related to the recipient (and might share some genetic trait that contributes to kidney disease) and donors who are not blood-related to their recipients. But this study seems to be a valuable step forward.
    Fr. Pat

[donor99]

We know that if a donor gets a kidney disease that their progression to dialysis would be faster than if they had 2 kidneys. This study is 15 years later, maybe too early for matched controls to develope ESRD? Maybe they had some level of CKD but not ESRD.? Would need more information on how this was conducted.

Potential donors need to understand that their risk of ESRD is the same as "people just like them" risk for blacks is higher than whites, if your whole family has HTN your risk is higher , if your family is diabetic your risk is higher etc....again the only difference is that you would progress to ESRD faster than people with two kidneys.