Utility of Estimated Glomerular Filtration Rate in Live Kidney Donation

[Clark]

http://m.cjasn.asnjournals.org/content/3/6/1608.full.pdf

Utility of Estimated Glomerular Filtration Rate in Live Kidney Donation
Ravi Parasuraman and K. K. Venkat
Clin J Am Soc Nephrol 3: 1608 –1609, 2008. doi: 10.2215/CJN.04840908

Live kidney donation is considered safe; nevertheless, data supporting such claims are almost exclusively of white origin with
very limited long-term outcomes in ethnic minority donors. This prospective observational study consisted of a total of 103
previous kidney donors (54 black and 49 white) with mean follow-up days of 743.5
603.9 for white and 845.1
668.5 for black
donors. The black donors had a statistically significant greater loss of estimated GFR (eGFR; 39.8 ml/min per 1.73 m2) in comparison with white donors (30.4 ml/min per 1.73 m2; P  0.001). In multivariate analysis, predonation eGFR of <100
ml/min and age at the time of donation were the significant predictors for postdonation eGFR <60 ml/min among black
donors. Because eGFR using the Modification of Diet in Renal Disease 4 formula is not validated in live kidney donors, the
significance of eGFR <60 ml/min per 1.73 m2
in previous kidney donors is unclear. Long-term prospective study with a gold
standard method such as iothalamate GFR measurement is needed to define the actual decrease in eGFR after kidney
donation.