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Author Topic: Review: Living kidney donation: outcomes, ethics, and uncertainty  (Read 1378 times)

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Offline Clark

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http://www.sciencedirect.com/science/article/pii/S0140673614624843#MMCvFirst

Review
Living kidney donation: outcomes, ethics, and uncertainty

Dr Peter P Reese, MD Prof Neil Boudville, MD Prof Amit X Garg, MD
Volume 385, Issue 9981
, 16–22 May 2015, Pages 2003–2013
doi:10.1016/S0140-6736(14)62484-3


Summary

Since the first living-donor kidney transplantation in 1954, more than half a million living kidney donations have occurred and research has advanced knowledge about long-term donor outcomes. Donors in developed countries have a similar life expectancy and quality of life as healthy non-donors. Living kidney donation is associated with an increased risk of end-stage renal disease, although this outcome is uncommon (<0·5% increase in incidence at 15 years). Kidney donation seems to elevate the risks of gestational hypertension and pre-eclampsia. Many donors incur financial expenses due to factors such as lost wages, need for sick days, and travel expenses. Yet, most donors have no regrets about donation. Living kidney donation is practised ethically when informed consent incorporates information about risks, uncertainty about outcomes is acknowledged when it exists, and a donor's risks are proportional to benefits for the donor and recipient. Future research should determine whether outcomes are similar for donors from developing countries and donors with pre-existing conditions such as obesity.

« Last Edit: June 13, 2015, 06:37:55 PM by Clark »
Unrelated directed kidney donor in 2003, 500+ time blood & platelet donor and counting!
Rep to the OPTN/UNOS Boards of Directors & Executive, Kidney Transplantation, & Ad Hoc Public Solicitation of Organ Donors Committees 2005-2011

 

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