Recipient factors associated with having a potential living donor for liver tran

[Clark]

http://onlinelibrary.wiley.com/doi/10.1002/lt.24148/abstract


Recipient factors associated with having a potential living donor for liver transplantation
      Adam Doyle1,†, Rania N. Rabie1,2,†, Arastoo Mokhtari1, Mark Cattral1, Anand Ghanekar1, David Grant1, Paul Greig1, Gary Levy1, Leslie Lilly1, Ian McGilvray1, Markus Selzner1, Nazia Selzner1 andEberhard L. Renner1,*
Article first published online: 23 JUN 2015
DOI: 10.1002/lt.24148

Liver Transplantation
Early View (Online Version of Record published before inclusion in an issue)

      Abstract
Because of a persistent discrepancy between the demand for liver transplantation (LT) and the supply of deceased donor organs, there is an interest in increasing living donation rates at centers trained in this method of transplantation. We examined a large socioeconomically heterogeneous cohort of patients listed for LT to identify recipient factors associated with living donation. We retrospectively reviewed 491 consecutive patients who were listed for LT at our center over a 24-month period. Demographic, medical, and socioeconomic data were extracted from electronic records and compared between those who had a potential living donor (LD) volunteer for assessment and those who did not; 245 patients (50%) had at least 1 potential LD volunteer for assessment. Multivariate logistic regression analysis identified that patients with a LD were more likely to have Child-Pugh C disease (odds ratio [OR], 2.44; P = 0.02), and less likely to be older (OR, 0.96; P = 0.002), single (OR, 0.34; P = 0.006), divorced (OR, 0.53; P = 0.03), immigrants (OR, 0.38; P = 0.049), or from the lowest income quintile (OR, 0.44; P = 0.02). In conclusion, this analysis has identified several factors associated with access to living donation. More research is warranted to define and overcome barriers to living donor liver transplantation through targeted interventions in underrepresented populations.