« on: April 22, 2022, 09:42:56 AM »
https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16826?campaign=woletocRethinking incompatibility in kidney transplantationAmerican Journal of TransplantationVolume22, Issue4April 2022Pages 1031-1036Kyle R. Jackson, Dorry L. SegevFirst published: 31 August 2021 https://doi.org/10.1111/ajt.16826AbstractDonor/recipient incompatibility in kidney transplantation classically refers to ABO/HLA-incompatibility. Kidney paired donation (KPD) was historically established to circumvent ABO/HLA-incompatibility, with the goal of identifying ABO/HLA-compatible matches. However, there is a broad range of donor factors known to impact recipient outcomes beyond ABO/HLA-incompatibility, such as age and weight, and quantitative tools are now available to empirically compare potential living donors across many of these factors, such as the living donor kidney donor profile index (LKDPI). Moreover, the detrimental impact of mismatch at other HLA antigens (such as DQ) and epitope mismatching on posttransplant outcomes has become increasingly recognized. Thus, it is time for a new paradigm of incompatibility that considers all of these risks factors together in assessing donor/recipient compatibility and the potential utility for KPD. Under this new paradigm of incompatibility, we show how the LKDPI and other tools can be used to identify donor/recipient incompatibilities that could be improved through KPD, even for those with a traditionally "compatible" living donor.

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Unrelated directed kidney donor in 2003, my recipient and I are well.
640 time blood and platelet donor since 1976 and still giving!
Elected to the OPTN/UNOS Boards of Directors & Executive, Kidney Transplantation, and Ad Hoc Public Solicitation of Organ Donors Committees, 2005-2011
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