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Author Topic: The first successful case of ABO-incompatible living-donor lobar lung transplant  (Read 1988 times)

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Offline Clark

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https://www.amjtransplant.org/article/S1600-6135(23)00457-4/fulltext

CASE REPORT| VOLUME 23, ISSUE 9, P1451-1454, SEPTEMBER 2023

The first successful case of ABO-incompatible living-donor lobar lung transplantation following desensitization therapy

      Daisuke Nakajima

Itsuki Yuasa
Hidenao Kayawake


      Shiro Baba
Hidefumi Hiramatsu
Hiroshi Date
et al.

American Journal of Transplantation
Published:May 04, 2023

DOI:https://doi.org/10.1016/j.ajt.2023.04.031

Abstract
ABO-incompatible (ABO-I) living-donor lobar lung transplantation (LDLLT) was successfully performed in a 14-year-old girl who suffered from bronchiolitis obliterans due to graft-versus-host disease following hematopoietic stem cell transplantation. In the ABO-I LDLLT procedure, the blood type O patient received a right lower lobe donated from her blood type B father and a left lower lobe donated from her blood type O mother. Desensitization therapy, using rituximab, immunosuppressants, and plasmapheresis, was implemented for 3 weeks prior to transplantation to reduce the production of anti-B antibodies in the recipient and prevent acute antibody-mediated rejection after ABO-I LDLLT.
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