Preparing for transplant

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Hello everyone,
my wife is planning to be the donor for her sister. We're now in the screening phase and the important results are:

- lymphocyte crossmatch is negative

- HLA-A result are matching, while HLA-B and HLA-DR are not

- Donor proteinuria from the 24h urine test is 286. Normal levels are less than 150, but the doctor said less than 300 is OK for transplant

- They have both the same blood type.

I would like to ask from people that have done the transplant if the chances of a positive transplant from the above tests are good or not. The doctor is saying that it has high possibility to be successful, but I'm not so sure.

Thank you