Increasing the Number of Organ Transplants in the United States by Optimizing Do

[Clark]

http://onlinelibrary.wiley.com/doi/10.1111/ajt.13362/abstract



Increasing the Number of Organ Transplants in the United States by Optimizing Donor Authorization Rates
D. S. Goldberg1,2,3,*, B. French2,3, P. L. Abt4 andR. K. Gilroy5
Article first published online: 28 MAY 2015
DOI: 10.1111/ajt.13362
American Journal of Transplantation
Early View (Online Version of Record published before inclusion in an issue)

Abstract
While recent policies have focused on allocating organs to patients most in need and lessening geographic disparities, the only mechanism to increase the actual number of transplants is to maximize the potential organ supply. We conducted a retrospective cohort study using OPTN data on all "eligible deaths" from 1/1/08 to 11/1/13 to evaluate variability in donor service area (DSA)-level donor authorization rates, and to quantify the potential gains associated with increasing authorization rates. Despite adjustments for donor demographics (age, race/ethnicity, cause of death) and geographic factors (rural/urban status of donor hospital, statewide participation in deceased-donor registries) among 52 571 eligible deaths, there was significant variability (p < 0.001) in donor authorization rates across the 58 DSAs. Overall DSA-level adjusted authorization rates ranged from 63.5% to 89.5% (median: 72.7%). An additional 773–1623 eligible deaths could have been authorized, yielding 2679–5710 total organs, if the DSAs with authorization rates below the median and 75th percentile, respectively, implemented interventions to perform at the level of the corresponding reference DSA. Opportunities exist within the current organ acquisition framework to markedly improve DSA-level donor authorization rates. Such initiatives would mitigate waitlist mortality while increasing the number of transplants.