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By and For Living Donors
Recent posts
#11
Living Donation Forum / Re: Are you aware OPTN meeting...
Last post by Michael - September 27, 2025, 09:00:46 AMAre the videos recorded and accessible?
#12
Living Donation Forum / Are you aware OPTN meetings ar...
Last post by Clark - September 26, 2025, 02:44:21 PMhttps://vimeo.com/optn
Dr. Gonzalez is presenting the Living Donor Committee's proposal to improve living donor follow up data collection with the SRTR to the MPSC right now. If you don't know what these acronyms mean, or didn't know you, too, could provide feedback about this proposal and many others, please go to https://optn.transplant.hrsa.gov/ and explore!
Dr. Gonzalez is presenting the Living Donor Committee's proposal to improve living donor follow up data collection with the SRTR to the MPSC right now. If you don't know what these acronyms mean, or didn't know you, too, could provide feedback about this proposal and many others, please go to https://optn.transplant.hrsa.gov/ and explore!
#13
Using the Message Board / Re: Living Donors on Facebook
Last post by Michael - September 19, 2025, 01:21:03 PMThe LDO Facebook Group has been closed and replaced by a Facebook Page that you can find here: https://www.facebook.com/profile.php?id=61579185672724
#14
Living Donation Forum / We Have a New Facebook Page!
Last post by Michael - September 02, 2025, 08:13:44 AMAfter 12 years as a Facebook Group, we decided that the format of a Facebook Page is more appropriate for what we do. Therefore, we have closed the Group and replaced it with the "Living Donors Online" Facebook Page. You can find it here: https://www.facebook.com/profile.php?id=61579185672724
Please visit the Page and "Like" it so you can stay in touch. Thanks!
Michael
Please visit the Page and "Like" it so you can stay in touch. Thanks!
Michael
#15
Living Donation Forum / Re: September 2025 Living Dono...
Last post by Michael - September 02, 2025, 08:02:36 AMThanks for the acknowledgement! Yes, it's been 25 years since LDO started, and it's been a long and winding road.
A special "thank you" to you, John, for all you've done and continue to do to educate, support, and advocate for living donors!
A special "thank you" to you, John, for all you've done and continue to do to educate, support, and advocate for living donors!
#16
Living Donation in the News / india: More Women Than Men Ple...
Last post by Clark - September 01, 2025, 06:56:52 PMhttps://www.hercircle.in/engage/get-inspired/trending/more-women-than-men-pledge-to-donate-their-organs-when-applying-for-a-driverrsquos-license-9550.html
More Women Than Men Pledge To Donate Their Organs When Applying For A Driver's License
Not only do women make up the majority of living organ donors, but statistics also indicate that they outnumber men in terms of the percentage of applicants for driving licenses with the pledge to donate their organs in the event of a fatal accident. When applying for a driver's license, the Ministry of Road Transport and Highways introduced a provision to pledge for organ donation in the event of death.
...
More Women Than Men Pledge To Donate Their Organs When Applying For A Driver's License
Not only do women make up the majority of living organ donors, but statistics also indicate that they outnumber men in terms of the percentage of applicants for driving licenses with the pledge to donate their organs in the event of a fatal accident. When applying for a driver's license, the Ministry of Road Transport and Highways introduced a provision to pledge for organ donation in the event of death.
...
#17
Living Donation in the News / Factors Associated With Willin...
Last post by Clark - September 01, 2025, 03:05:58 PMhttps://www.researchgate.net/publication/394697939_Factors_Associated_With_Willingness_to_Become_a_Living_Organ_Donor
Factors Associated With Willingness to Become a Living Organ Donor August 2025JAMA Network Open 8(8):e2527592DOI:10.1001/jamanetworkopen.2025.27592
Taranika Sarkar Das, et al.
Abstract
Importance
Organ transplant demand in the US far exceeds supply. Living donor organ transplantation (LDOT) offers a critical solution to reducing this shortage, yet its adoption remains limited. Understanding factors that influence willingness to donate is essential for expanding the living donor pool.
Objective
To examine whether knowledge of LDOT, perceptions of fairness in the transplant system, geography, socioeconomic status, and religiosity are associated with individuals' willingness to become living organ donors.
Design, Setting, and Participants
This cross-sectional study analyzed responses from the 2019 National Survey of Organ Donation Attitudes and Practices (NSODAP). Participants were aged 18 years or older. Poststratification weights were applied to align the sample with US census demographic characteristics. Data were analyzed from November 2024 through May 2025.
Exposures
Socioeconomic status, region of residence, knowledge of living donation, perceptions of inequality in transplantation, and religiosity.
Main Outcome and Measures
The primary outcome was the self-reported likelihood of donating an organ to a family member while living. Composite scores were created to assess knowledge about living donation, perceptions of fairness in organ transplantation, and religiosity. Multivariable logistic regression was performed to evaluate associations with willingness to donate, adjusting for demographic and socioeconomic factors.
Results
Of the 9922 survey respondents, 5264 (53.2%) were women, and 7801 (78.9%) reported an educational level of postsecondary training or above. The largest proportion of participants was aged 18 to 34 years (3006 [32.6%]), followed by 50 to 64 years (2390 [25.9%]), and most had health insurance (8547 [86.1%]); 8667 (87.4%) reported being likely to donate. Women were more likely to report willingness to donate than men (odds ratio [OR], 1.49; 95% CI, 1.23-1.81; P < .001), and Asian participants were less likely to report willingness to donate than White participants (OR, 0.72; 95% CI, 0.55-0.94; P = .02). Higher knowledge scores were associated with increased willingness to donate (OR, 1.62; 95% CI, 1.49-1.77; P < .001), while lower perceptions of fairness in organ allocation were associated with decreased willingness (OR, 0.85; 95% CI, 0.78-0.92; P < .001). Conclusions and Relevance In this cross-sectional study analyzing survey data from NSODAP, willingness to become a living organ donor was associated with knowledge, perceptions of fairness within the organ transplant system, and socioeconomic factors. The findings suggest that targeted education and transparency in organ allocation policies may help expand the US living donor pool.
Factors Associated With Willingness to Become a Living Organ Donor August 2025JAMA Network Open 8(8):e2527592DOI:10.1001/jamanetworkopen.2025.27592
Taranika Sarkar Das, et al.
Abstract
Importance
Organ transplant demand in the US far exceeds supply. Living donor organ transplantation (LDOT) offers a critical solution to reducing this shortage, yet its adoption remains limited. Understanding factors that influence willingness to donate is essential for expanding the living donor pool.
Objective
To examine whether knowledge of LDOT, perceptions of fairness in the transplant system, geography, socioeconomic status, and religiosity are associated with individuals' willingness to become living organ donors.
Design, Setting, and Participants
This cross-sectional study analyzed responses from the 2019 National Survey of Organ Donation Attitudes and Practices (NSODAP). Participants were aged 18 years or older. Poststratification weights were applied to align the sample with US census demographic characteristics. Data were analyzed from November 2024 through May 2025.
Exposures
Socioeconomic status, region of residence, knowledge of living donation, perceptions of inequality in transplantation, and religiosity.
Main Outcome and Measures
The primary outcome was the self-reported likelihood of donating an organ to a family member while living. Composite scores were created to assess knowledge about living donation, perceptions of fairness in organ transplantation, and religiosity. Multivariable logistic regression was performed to evaluate associations with willingness to donate, adjusting for demographic and socioeconomic factors.
Results
Of the 9922 survey respondents, 5264 (53.2%) were women, and 7801 (78.9%) reported an educational level of postsecondary training or above. The largest proportion of participants was aged 18 to 34 years (3006 [32.6%]), followed by 50 to 64 years (2390 [25.9%]), and most had health insurance (8547 [86.1%]); 8667 (87.4%) reported being likely to donate. Women were more likely to report willingness to donate than men (odds ratio [OR], 1.49; 95% CI, 1.23-1.81; P < .001), and Asian participants were less likely to report willingness to donate than White participants (OR, 0.72; 95% CI, 0.55-0.94; P = .02). Higher knowledge scores were associated with increased willingness to donate (OR, 1.62; 95% CI, 1.49-1.77; P < .001), while lower perceptions of fairness in organ allocation were associated with decreased willingness (OR, 0.85; 95% CI, 0.78-0.92; P < .001). Conclusions and Relevance In this cross-sectional study analyzing survey data from NSODAP, willingness to become a living organ donor was associated with knowledge, perceptions of fairness within the organ transplant system, and socioeconomic factors. The findings suggest that targeted education and transparency in organ allocation policies may help expand the US living donor pool.
#18
Living Donation in the News / Comparative analysis of outcom...
Last post by Clark - September 01, 2025, 02:41:34 PMhttps://www.researchgate.net/journal/PLOS-One-1932-6203/publication/394973980_Comparative_analysis_of_outcomes_in_high_KDPI_spectrum_kidney_transplants_using_unsupervised_machine_learning_algorithm/links/68adfc742c7d3e0029b3b0f7/Comparative-analysis-of-outcomes-in-high-KDPI-spectrum-kidney-transplants-using-unsupervised-machine-learning-algorithm.pdf?origin=journalDetail
Comparative analysis of outcomes in high KDPI spectrum kidney transplants using unsupervised machine learning algorithm
Mahmoudreza Moein, et al.
PLoS One 20(8): e0324265. https://doi.org/10.1371/journal.pone.0324265
Abstract
Background
The Kidney Donor Profile Index (KDPI) is a continuous metric used to estimate the risk of allograft failure for kidneys from deceased donors. Lower KDPI scores are associated with longer post-transplant kidney function. This study aims to evaluate the outcomes of kidney transplantation using high-KDPI kidneys (98–100%) compared to those with moderately high KDPI scores (85–97%), employing a novel case-matching approach using machine learning.
Methods
We conducted a retrospective analysis of the United Network for Organ Sharing (UNOS) database, examining kidney transplants performed in the United States between January 2000 and May 2020. An unsupervised machine learning algorithm was used to match recipients of KDPI 98–100% kidneys with recipients of KDPI 85–97% kidneys based on key baseline characteristics, including recipient age, body mass index (BMI), cold ischemia time, HLA mismatch, ethnicity, and gender.
Results
A total of 6,624 matched cases were selected for analysis. The mean follow-up duration was 4.5 years for the KDPI 98–100% cohort and 4.6 years for the KDPI 85–97% cohort. The five-year allograft survival was 51.7% for the KDPI 98–100% group versus 58% for the KDPI 85–97% group (P<0.001). Asian recipients showed the highest survival in both cohorts (68% vs. 69%). Donation after circulatory death (DCD) status did not significantly impact outcomes. Across the full cohort, 1,819 cases of allograft failure were recorded, with chronic rejection being the leading cause (28.4% vs. 30%, P=0.56).
Conclusion
Transplantation with high-KDPI kidneys, though associated with lower survival rates, remains a viable option for expanding the donor pool. With appropriate recipient selection, high-KDPI kidneys can improve patient quality of life, reduce wait times, and lower healthcare costs. Our findings support a more nuanced approach to organ allocation using advanced matching strategies.
Comparative analysis of outcomes in high KDPI spectrum kidney transplants using unsupervised machine learning algorithm
Mahmoudreza Moein, et al.
PLoS One 20(8): e0324265. https://doi.org/10.1371/journal.pone.0324265
Abstract
Background
The Kidney Donor Profile Index (KDPI) is a continuous metric used to estimate the risk of allograft failure for kidneys from deceased donors. Lower KDPI scores are associated with longer post-transplant kidney function. This study aims to evaluate the outcomes of kidney transplantation using high-KDPI kidneys (98–100%) compared to those with moderately high KDPI scores (85–97%), employing a novel case-matching approach using machine learning.
Methods
We conducted a retrospective analysis of the United Network for Organ Sharing (UNOS) database, examining kidney transplants performed in the United States between January 2000 and May 2020. An unsupervised machine learning algorithm was used to match recipients of KDPI 98–100% kidneys with recipients of KDPI 85–97% kidneys based on key baseline characteristics, including recipient age, body mass index (BMI), cold ischemia time, HLA mismatch, ethnicity, and gender.
Results
A total of 6,624 matched cases were selected for analysis. The mean follow-up duration was 4.5 years for the KDPI 98–100% cohort and 4.6 years for the KDPI 85–97% cohort. The five-year allograft survival was 51.7% for the KDPI 98–100% group versus 58% for the KDPI 85–97% group (P<0.001). Asian recipients showed the highest survival in both cohorts (68% vs. 69%). Donation after circulatory death (DCD) status did not significantly impact outcomes. Across the full cohort, 1,819 cases of allograft failure were recorded, with chronic rejection being the leading cause (28.4% vs. 30%, P=0.56).
Conclusion
Transplantation with high-KDPI kidneys, though associated with lower survival rates, remains a viable option for expanding the donor pool. With appropriate recipient selection, high-KDPI kidneys can improve patient quality of life, reduce wait times, and lower healthcare costs. Our findings support a more nuanced approach to organ allocation using advanced matching strategies.
#19
Living Donation in the News / King approves awarding King Ab...
Last post by Clark - September 01, 2025, 02:30:45 PMhttps://saudigazette.com.sa/article/654520/SAUDI-ARABIA/King-approves-awarding-King-Abdulaziz-Medal-to-200-Saudi-organ-donors
King approves awarding King Abdulaziz Medal to 200 Saudi organ donors
Custodian of the Two Holy Mosques King Salman has approved awarding the King Abdulaziz Medal of the Third Class to 200 Saudi male and female citizens who have donated their organs.
King approves awarding King Abdulaziz Medal to 200 Saudi organ donors
Custodian of the Two Holy Mosques King Salman has approved awarding the King Abdulaziz Medal of the Third Class to 200 Saudi male and female citizens who have donated their organs.
#20
Living Donation in the News / Xenotransplantation: Scientist...
Last post by Clark - September 01, 2025, 02:21:20 PMhttps://www.nature.com/articles/s41591-025-03861-x
https://singularityhub.com/2025/08/28/in-a-first-scientists-transplant-a-modified-pig-lung-into-a-person/
In a First, Scientists Transplant a Modified Pig Lung Into a Person
https://singularityhub.com/2025/08/28/in-a-first-scientists-transplant-a-modified-pig-lung-into-a-person/
In a First, Scientists Transplant a Modified Pig Lung Into a Person